SINCE Wwii, medical science has progressed to a stage where competitive medications are around to treat precisely the same ailment in different people. It’s not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall look at the various factors that decide selecting a certain drug.
Safety: The subsequent sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even if it’s got certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the opportunity side-effect of addiction.
* Long-term safety: medicine could possibly be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals reply to create a different chemical, that have an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other person, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This leads to a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same effect on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicine is more intense.
Tolerability: A medicine could possibly be effective but not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability must be considered. Efficacy: A medicine isn’t equally great at all patients. For instance, some patients with depression or panic disorders experience reduced escitalopram, but there are lots of who don’t, who therefore must be prescribed another anti-depressant. The rate of start of therapeutic action is an important key to be regarded too.
Cost: Cost does not mean the price tag on purchase of a specific medicine alone. It ought to also cover the price tag on treating a complication that could arise from utilizing another drug. Example: Inside a individual that insists on taking alcohol nevertheless needs to be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (for example tricyclics) could cause a brand new symptom in such patients, which would require a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simple treatment: The easiest mode of administration is preferred. When there is a choice between a shot and oral administration, aforementioned is preferred if the efficacy of the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to determine simple treatment.
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