SINCE Wwii, medical science has progressed with a stage where competitive medications are around to treat precisely the same ailment in numerous people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall go through the various factors that decide your selection of a certain drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even if it’s certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the potential side-effect of addiction.
* Long-term safety: drug may be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals reply to produce a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This leads to an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually generate the same influence on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicines are more serious.
Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability must be looked at. Efficacy: A medication just isn’t equally efficient at all patients. By way of example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of that don’t, who therefore must be prescribed an alternative anti-depressant. The rate of beginning of therapeutic action is a factor to be regarded as too.
Cost: Cost does not always mean the cost of purchase of a certain medicine alone. It must also cover the cost of treatments for a complication that may arise from using an alternative drug. Example: Inside a individual who insists on taking alcohol but needs to be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (for example tricyclics) might cause a new condition in such patients, which may need a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. If there is an alternative between a shot and oral administration, the latter is preferred in the event the efficacy of both modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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