SINCE Wwii, medical science has progressed to some stage where competitive medications are for sale to treat precisely the same ailment in various people. This is simply not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall look at the various factors that decide picking a a particular drug.
Safety: The next sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug regardless of whether it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the opportunity side-effect of addiction.
* Long-term safety: medication might be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals react to make a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same impact on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the drugs are more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medication is not equally great at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are lots of who don’t, who therefore should be prescribed a different anti-depressant. The speed of start of therapeutic action is a crucial the answer to be regarded as too.
Cost: Cost does not mean the price of purchase of a specific medicine alone. It ought to also cover the price of management of a complication that may arise from utilizing a different drug. Example: Within a one who insists on taking alcohol nevertheless has to be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (for example tricyclics) may cause a brand new problem in such patients, which could demand a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you find a choice between a shot and oral administration, the latter is preferred if your efficacy of both the modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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