SINCE World war 2, medical science has progressed to a stage where competitive medications are for sale to treat exactly the same ailment in various people. This is simply not pretty much brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall look at the various factors that decide the selection of a selected drug.
Safety: The subsequent sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug even when it has certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but come with the opportunity side-effect of addiction.
* Long-term safety: directory may be safe in short-term treatment, but how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals reply to develop a different chemical, which has an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same influence on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the prescription medication is more intense.
Tolerability: A drug may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability must be looked at. Efficacy: A drug is just not equally efficient at all patients. For example, some patients with depression or panic attacks experience reduced escitalopram, but there are lots of that do not, who therefore must be prescribed another anti-depressant. The speed of start of therapeutic action is a vital the answer to be considered too.
Cost: Cost does not necessarily mean the price of purchase of a specific medicine alone. It must also cover the price of treatment of a complication that could arise while using another drug. Example: In the individual who insists on taking alcohol but should be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (like tricyclics) could cause a whole new problem in such patients, which may need a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.
Simplicity of treatment: The easiest mode of administration is preferred. When there is an option between an injection and oral administration, the latter is preferred in the event the efficacy of both the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to decide simplicity of treatment.
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