SINCE World war 2, medical science has progressed with a stage where competitive medications are around for treat exactly the same ailment in numerous people. This is simply not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall go through the various factors that decide picking a a selected drug.
Safety: The following sub-criteria have to be considered underneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug regardless of whether it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.
* Long-term safety: medication might be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals react to make a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually generate the same impact on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the medicines are more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability need to be looked at. Efficacy: A medication is not equally great at all patients. For example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are lots of who don’t, who therefore need to be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is an important factor to be considered too.
Cost: Cost doesn’t imply the cost of acquisition of a particular medicine alone. It ought to also cover the cost of treatment of a complication that may arise from utilizing an alternative drug. Example: In a person who insists on taking alcohol nevertheless should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (such as tricyclics) could cause a fresh overuse injury in such patients, which may demand a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic in this patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is an alternative between an injection and oral administration, rogues is preferred if the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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