SINCE World war 2, medical science has progressed with a stage where competitive medications are around to treat the identical ailment in several people. It’s not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall look at the various factors that decide selecting a selected drug.
Safety: These sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even when it’s got certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the possible side-effect of addiction.
* Long-term safety: drug may be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and many chemicals respond to develop a different chemical, which has an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually make the same influence on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the medicines are more intense.
Tolerability: A drug may be effective however, not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability must be taken into account. Efficacy: A drug isn’t equally good at all patients. For example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of who don’t, who therefore must be prescribed an alternative anti-depressant. The interest rate of onset of therapeutic action is a vital factor to be regarded as too.
Cost: Cost does not necessarily mean the price tag on buying a particular medicine alone. It must also cover the price tag on treatments for a complication that may arise from using an alternative drug. Example: Inside a individual that insists on taking alcohol and yet should be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) could cause a new overuse injury in such patients, which would have to have a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in such patients.
Simple treatment: Most effective mode of administration is preferred. If there is an alternative between a shot and oral administration, aforementioned is preferred when the efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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