SINCE World War II, medical science has progressed to a stage where competitive medications are around for treat the same ailment in several people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall consider the various factors that decide selecting a certain drug.
Safety: The following sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug even though it has certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicationdirectory.com may be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals answer produce a different chemical, that have an effect which could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects using one or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A medication may be effective although not tolerable by all patients. Example: Allergies to particular drugs in a few people. Short-term and long-term tolerability need to be considered. Efficacy: A medication just isn’t equally effective in all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are many who don’t, who therefore need to be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is a vital the answer to be looked at too.
Cost: Cost doesn’t imply the expense of buying a particular medicine alone. It will also cover the expense of management of a complication which could arise from using some other drug. Example: Within a person who insists on taking alcohol nevertheless must be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (including tricyclics) can cause a fresh symptom in such patients, which will have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic in this patients.
Simple treatment: The simplest mode of administration is preferred. If you have a choice between an injection and oral administration, the latter is preferred if the efficacy of the modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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