SINCE World War II, medical science has progressed into a stage where competitive medications are around to treat precisely the same ailment in various people. This is not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall go through the various factors that decide the selection of a specific drug.
Safety: These sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: medicationdirectory.com could possibly be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals respond to create a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects using one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same effect on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two medicine is more intense.
Tolerability: A medicine could possibly be effective but not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability must be considered. Efficacy: A medicine just isn’t equally great at all patients. For instance, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several who don’t, who therefore must be prescribed another anti-depressant. The interest rate of oncoming of therapeutic action is a vital step to be looked at too.
Cost: Cost does not necessarily mean the expense of acquisition of a particular medicine alone. It must also cover the expense of treatments for a complication that will arise while using another drug. Example: Inside a one who insists on taking alcohol nevertheless should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (for example tricyclics) might cause a new symptom in such patients, which would need a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is an option between an injection and oral administration, the latter is preferred if your efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to choose simplicity of treatment.
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